We know that accumulation of amyloid-beta proteins in the brain is one of the main features of Alzheimer’s. But did you know that the same proteins are also present in other (periphereral) organs and that there is a possibility that these proteins are interrelated with each other?
To test this statement, a recent study used a mouse model that produced the same human amyloid-beta protein only in liver cells. The study showed that the protein was carried in the blood by triglyceride-rich lipoproteins, just as it is in people, and passed from the liver into the brain. As a result, mice developed neurodegeneration and their brain volume decreased (brain atrophy), which was accompanied by inflammation and dysfunction of blood vessels in the brain (both are typical for Alzheimer’s). In consequence, mice performed poorly on a learning test.
These findings mean that amyloid-beta protein made in the liver, the peripheral organ, can cause neurodegeneration in the brain and therefore can be a potential contributor to human disease. If that contribution is significant, than it might bring us a step further in understanding Alzheimer’s disease.
Up-to-date, the overproduction and accumulation of amyloid-beta protein in the brain is due to the existing “turned-on” Alzheimer’s gene. However, in the most cases of this disease, overproduction of amyloid-beta in the brain alone is not enough to start the disease. Instead, lifestyle factors may play here a more significant role, including a high-fat diet, which might accelerate liver production of amyloid.
As you see, here we have another scientific proof that healthy lifestyle is a key to healthy aging brain. Take care of yourself!
Curious? HERE is the source