B3 has different forms, where nicotinamide riboside (NR) is the most important one in case of Parkinson’s. It serves as a raw material for the essential metabolic factor NAD (nicotinamide adenine dinucleotide), which is vital to various cellular processes, including energy metabolism, DNA damage repair, control of gene expression and stress resistance of our brain cells.
People with Parkinson’s turned to have disturbances in NAD metabolism, what causes disbalance in brain’s energy and other cellular processes, leading to disease. That is why boosting NAD levels efficiently might help people with Parkinson’s. And the results of the phase I of a recent randomized, double-blinded trial showed that the NAD levels of the human brain can be increased by supplementing NR, an NAD-precursor.
In this ongoing trial 30 individuals with early Parkinson’s disease received either 1.000 mg NR or placebo for 30 days. The results were astonishing. NR supplementation significantly increased NAD levels in the brain, and led to changed brain’s energy metabolism and decreased inflammation in the fluid surrounding the brain and spinal cord. Moreover, participants with substantially increased brain NAD levels after supplementation, had mild but significant improvements of Parkinson’s disease symptoms.
The researchers believe that the first results of their ongoing trial might help not only people with Parkinson’s, but also people with other age-related and neurodegenerative diseases. This is because NR proved to be able to optimize the metabolism in the brain and fortify neurons.
As a reminder, NR supplementation is not the only one method to increase your NAD levels. Food, rich in B3, exercises, and other lifestyle aspects can help keeping your NAD at an optimal level!
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