According to a recent study, infusions of the local anesthetic lidocaine may be helpful for people with chronic migraine who don’t respond to any other treatment.

“Laughing gas” is another name for nitrous oxide gas that is often used as a pain reliever by surgeons and dentists. In the dose of 50% it has also shown to be able to relieve depressive symptoms fast in antidepressant treatment-resistant people. However, this non-traditional treatment has also side effects like nausea, vomiting and headaches.